鲍岚
博士，特聘研究员
Email:baolan@@gdiist.cn
个人简介
鲍岚研究员，广东省智能科学与技术研究院特聘研究员，原中国科学院分子细胞科学卓越创新中心课题组长、博士生导师，2003年获国家自然科学杰出青年基金资助，2008年获中科院“百人计划”资助。主要从事神经系统调控的分子细胞机制研究，已在国际学术期刊发表80余篇学术论文。曾承担国家自然科学基金重点项目和国家重大研究计划项目，获得军队科技进步一等奖和二等奖各1次、上海市科学技术进步二等奖1次。享受国务院政府特殊津贴，获上海市“三八”红旗手荣誉称号、中国科学院朱月李华优秀教师奖、上海市志愿服务先进集体、中国细胞生物学学会科普工作先进分子。现兼任中国神经科学学会常务理事、中国细胞生物学学会常务理事、上海市创新细胞生物学发展基金会副理事长、中国细胞生物学学会女科学家工作委员会副主任。
代表论著：(*corresponding author)
1.Chen Y, Chen Q, Song Y, Wang H, Hu X, Wang K, Wu X, Xu F, Bao L and Zhang X. (2024) Tracing from periphery to cortex: application of herpes simplex virus to somatosensory neural networks. Neurosci. Bull, 40: 1739–1744.
2.Diao L, Liu M, Liu Y, Zhang X and Bao L*. (2023) Microtubules composed of α4A undergo curved growth mainly mediated by its core structure. J Mol Cell Biol, 15: mjad004.
3.Wang B, Jiang B, Li GW, Dong F, Luo Z, Cai B, Wei M, Huang J, Wang K, Feng X, Tong F, Wang S, Wang Q, Han Q, Li C, Zhang X, Yang L and Bao L*. (2022) Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Reports, 24: e54313.
4.Huang J, Jiang B, Li GW, Zheng D, Li M, Xie X, Pan Y, Wei M, Liu X, Jiang X, Zhang X, Yang L, Bao L* and Wang B*. (2022) m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Rep, 41: 111693.
5.Zhang S, Cai B, Li Z, Wang KK, Bao L, Li CL and Zhang X. (2022) Fibroblastic SMOC2 suppresses mechanical nociception by inhibiting coupled activation of primary sensory neurons. J Neurosci, 42: 4069-4086.
6.Diao L, Liu MY, Song YL, Zhang X, Liang X* and Bao L*. (2021) α1A and α1C form microtubules to display distinct properties mainly mediated by their C-terminal tails. J Mol Cell Biol, 13: 864-875.
7.Xie X, Wang SG, Li MY, Diao L, Pan XY, Chen JJ, Zhang X, Feng WF* and Bao L*. (2021) α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. Nat Commun, 12: 4113.
8.Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J, Bao L*, Zhang X*. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021.
9.Wang K, Wang S, Chen Y, Wu D, Hu X, Lu YJ, Wang L, Bao L, Li CL and Zhang X. (2021) Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain. Cell Res, 31: 904-918.
10.Wei MY, Huang JS, Li GW, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* and Wang B*. (2021) Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation. Cell Rep, 35: 109053.
11.Feng WF, Liu R, Xie X, Diao L, Gao NN, Cheng JK, Zhang X, Li Y and Bao L*. (2021) SUMOylation of α-tubulin is a novel modification regulating microtubule dynamics. J Mol Cell Biol, 13: 91–103.
12.Dong F, Shi HX, Yang L, Xue HQ, Wei MY, Zhong YQ, Bao L* and Zhang X*. (2020) FGF13 is required for histamine-induced itch sensation by interaction with NaV1.7. J Neurosci, 40: 9589-9601.
13.Li JY, Shi HX, Liu H, Dong F, Liu ZP, Lu YJ, Chen LN, Bao L* and Xu Zhang*. (2020) Nerve injury-induced neuronal PAP-I maintains neuropathic pain by activating spinal microglia. J Neurosci, 40: 297-310.
14.Wei D, Gao NN, Li L, Zhu JX, Diao L, Huang JS, Han QJ, Wang SG, Xue HQ, Wang Q, Wu QF, Zhang X and Bao L*. (2018) α-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons. Cerebral Cortex, 28: 3332-3346.
15.Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L, Bao L and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron, 93: 806-821.
16.Wang B and Bao L*. (2017) Axonal microRNAs: localization, function and regulatory mechanism during axon development. J. Mol. Cell Biol., 9: 82-90.
17.Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS and Zhang X. (2016) Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res., 26: 83-102.
18.Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Rep, 13: 2794-2807.
19.Bao L*. (2015) Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol. Pain, 11: 61
20.Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153.
21.Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896.
22.Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling. J. Cell Sci., 126: 542-553.
23.Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.
24.Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.
25.Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.
26.Zhao B, Wang HB, Lu YJ, Hu JW, Bao L and Zhang X. (2011) Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res., 21: 741-753.
27.He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.
28.Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.
29.Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TGM, Bao L*, and Zhang X*. (2010) Coexpression of δ- and µ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122.
30.Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.
31.Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165–2179.
32.Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J. Cell Sci. 121: 3243-3252.
