王飒爽
博士，助理研究员
Email：wangsashuang@@gdiist.cn
个人简介：
2014年于河南大学取得学士学位，2021年在中国科学院脑科学与智能技术卓越创新中心（中科院神经所）获神经生物学博士学位。研究成果主要发表于Cell Research、Neurosci Bull和J Neurosci等杂志。曾主持国家自然科学基金青年基金项目，作为科研骨干参与国家自然科学基金重大项目课题。
主要研究方向：
博士研究生期间主要利用单细胞测序技术研究外周神经损伤后基因表达变化及调控机制，筛选治疗神经病理性痛的药物靶点。目前的工作方向为躯体感觉相关疾病，基于大数据分析探索神经病理性痛、慢性痒等躯体感觉相关疾病的发生发展机制。利用10x Genomics单细胞测序、在体RNA干扰、RNAscope原位杂交、体外钙成像等技术，发掘新的关键靶点。
代表论著
1. Wu S#, Wang S#, Lin X, Yang S, Ba X, Xiong D, Xiao L, Li R. Lanatoside C inhibits herpes simplex virus 1 replication by regulating NRF2 distribution within cells. Phytomedicine. 2024 Feb;124:155308. (#, co-first authors)
2. Cai B, Wu D, Xie H, Chen Y, Wang H, Jin S, Song Y, Li A, Huang S, Wang S, Lu Y, Bao L, Xu F, Gong H, Li C, Zhang X. A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Res. 2023 Oct;33(10):775-789.
3. Luo QT, Ye YC, Guo WM, Zhu Q, Wang SS, Li N, Wang L, Cheng CS, Fan G. Senolytic Treatment Improve Small Intestine Regeneration in Aging. Aging Dis. 2023 Sep 26.
4. Wang B, Jiang B, Li GW, Dong F, Luo Z, Cai B, Wei M, Huang J, Wang K, Feng X, Tong F, Wang S, Wang Q, Han Q, Li C, Zhang X, Yang L, Bao L. Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Rep. 2023 Feb 6;24(2):e54313.
5. Yang S, Liu X, Wang M, Cao D, Jaijyan DK, Enescu N, Liu J, Wu S, Wang S, Sun W, Xiao L, Gu A, Li Y, Zhou H, Tyagi S, Wu J, Tang Q, Zhu H. Circular RNAs Represent a Novel Class of Human Cytomegalovirus Transcripts. Microbiol Spectr. 2022 Jun 29;10(3): e0110622.
6. Wu D, Li Z, Wang SS, Zhang S, Lu YJ, Bao L, Zhang X, Li CL. Zcchc12-Containing Nociceptors Are Required for Noxious Heat Sensation. J Neurosci. 2022 Mar 30;42(13):2690-2700.
7. Zhou J, Sun W, Liu Y, Yang S, Wu S, Wang S, Xiong D, Ho IH, Zhang L, Chan MTV, Wu WKK, Liu X, Xiao L. Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis. Pain Ther. 2021 Dec;10(2):1511-1522.
8. Wang KK#, Wang SS#, Chen Y, Wu D, Hu XY, Lu YJ, Wang LP, Bao L, Li CL*, Zhang X*. Single-Cell Transcriptomic Analysis of Somatosensory Neurons Uncovers Temporal Development of Neuropathic Pain. Cell Res. 2021 Aug;31(8):904-918. (#, co-first authors; *, co-corresponding authors)
9. Li CL, Wang SS, Chen Y, Zhang X. Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis. Neurosci Bull. 2018 Feb;34(1):200-207.
10. Li CL#, Li KC#, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS, Zhang X. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res. 2016; 26:83-102.
