丘志海
博士，研究员，研究组组长
致力于开发光和声无创脑成像和神经调控技术，并将其应用于脑功能研究和脑疾病治疗。
主要研究方向：
多尺度神经网络成像和操控
Email: qiuzhihai@@gdiist.cn
个人简介：
2019年毕业于香港理工大学生物医学工程专业，获生物医学工程博士学位。2019-2022年在美国斯坦福大学医学院从事博士后研究。获得多项国际会议（包括神经科学、生物物理、生物医学工程、光学工程等领域权威国际会议）奖项。相关研究成果在PNAS、Cell Reports、iScience、Advanced Science、 Brain stimulation, Advanced Photonics Research、IEEE TUFFC、STAR Protocols等学术期刊上发表。主持国自然面上项目1项。申请中国发明专利6项，美国专利4项。受邀在牛津大学《经颅脑调控工具书》撰写超声神经调控章节。是STAR Protocols杂志的Advisory board member。
多尺度神经网络成像和操控研究组：
目前主要聚焦超声神经调控和超声脑功能成像技术及其应用研究。
超声波是一种较安全的能量形式，在脑功能成像和神经调控中显示出越来越明朗的应用前景。平面波超声可以快速对全脑的血流灌注进行成像，得到类似于血氧水平依赖性功能磁共振（BOLD-fMRI）信息。超声系统相对简单和小巧，相比于功能核磁可以用较低的成本实现自由移动生物体的全脑功能成像。我们开发了全胚胎功能成像策略，有望成为临床产检新方法，为胚胎发育研究提供新技术新方法。另一方面，研究显示低能量低频率聚焦超声作为一种机械波，可以打开机械敏感通道蛋白，在神经刺激、神经-免疫调控等方面都有很大的应用前景。我们从中发展起来了基于MscL-G22s（一种细菌中发现的机械敏感通道蛋白）的超声遗传学技术，已经被法国学者独立验证，日益受到关注。在这些研究基础上，我们正致力于开发全声学的跨尺度神经网络成像和操控技术（包括基于超声遗传学的全脑神经网络解构方法、全脑-脊成像和刺激技术），并探索它们在临床前和临床转化中的应用。
此外，为了拓展光和声在颅骨和脑组织中的穿透深度，我们正在开发光和声的波前调控技术，希望推动光和声相关技术在基础研究和临床转化中的应用。
本课题组长期招聘联合培养博士生，FPGA工程师，感兴趣的同学，请邮件联系。
代表论著：
[1] Jiejun Zhu, Dongming He, Mengzhu Sun, Hanming Zheng, Zihao Chen, Jing Yang, Chengqi Lin, Yun Stone Shi, Lei Sun,* Zhihai Qiu*. Functional imaging of whole mouse embryonic development in utero. bioRxiv, 2024
[2] Xuandi Hou, Jianing Jing, Yizhou Jiang, Xiaohui Huang, Quanxiang Xian, Ting Lei, Jiejun Zhu, Kin Fung Wong, Xinyi Zhao, Min Su, Danni Li, Langzhou Liu, Zhihai Qiu, Lei Sun*. Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice. Nature Communications, 2024, 15(1): 2253
[3] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Derek King Fung Wong, Yong Wu, Xuandi Hou, Jinghui Guo, Lei Sun*. Modulation of deep neural circuits with sonogenetics. PNAS, 2023, 120(23): e2220575120
[4] Jiejun Zhu, Quanxiang Xian, Xuandi Hou, Kin Fung Wong, Tingting Zhu, Zihao Chen, Dongming He, Shashwati Kala, Suresh Murugappan, Jianing Jing, Yong Wu, Xinyi Zhao, Danni Li, Jinghui Guo, Zhihai Qiu*, Lei Sun*. The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. PNAS, 2023, 120(18): e2300291120
[5] Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu*. Sonogenetics: Recent advances and future directions. Brain stimulation, 2022, 15(5): 1308-1317
[6] Na Li, Zihao Chen, Jiejun Zhu, Mi Hyun Choi, Jin Yang, Zhen Yuan, Lei Sun, Chunlong Fei, Zhihai Qiu*. Measuring sound velocity based on acoustic resonance using multiple narrow band transducers. Heliyon, 2023, 9(3): 230145
[7] Zhihai Qiu, Mihyun Choi, Ningrui Li, Kim Butts Pauly, Direct neural activation by ultrasound. (In preparation)
[8] Zhihai Qiu, Shashwati Kala, Jinghui Guo, Quanxiang xian, Jiejun Zhu, Ting Zhu, Xuandi Hou, King Fung Wong, Minyi Yang, Haoru Wang, Lei Sun*. Targeted neurostimulation in mouse brains with non-invasive ultrasound. Cell Reports, 2020, 32(7), 108033
[9] Zhihai Qiu, Jinghui Guo, Shashwati Kala, Jiejun Zhu, Quanxiang Xian, Weibao Qiu, Guofeng Li, Ting Zhu, Long Meng, Rui Zhang, Hsiao Chang Chan, Hairong Zheng*, Lei Sun*. The mechanosensitive ion channel Piezo1 significantly mediates in vitro ultrasonic stimulation of neurons. iScience, 2019, 21: 448-457
[10] Xuandi Hou#,Zhihai Qiu#, Jinghui Guo, Ting Zhu, Lei Sun*, Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced Science, 2021, 2101934
[11] Keith R Murphy, Jordan S Farrell, Juan L Gomez, Quintin G Stedman, Ningrui Li, Steven A Leung, Cameron H Good, Zhihai Qiu, Kamyar Firouzi, Kim Butts Pauly, Butrus Pierre T Khuri-Yakub, Michael Michaelides, Ivan Soltesz, Luis de Lecea. A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy. PNAS, 2022, 119(46): e2206828119
[12] Tianting Zhong#, Zhihai Qiu#, Jinhui Guo, Huanhao Li, Zhipeng Yu, Shengfu Cheng, Yingying Zhou, Jiejun Zhu, Jie Tian*, Lei Sun*, and Puxiang Lai*, Spatiotemporally engineered neuron stimulation (STENS) through mouse skull with a wavefront shaping-empowered multimode fiber. Advanced photonic research, accepted
[13] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jiejun Zhu, Jinghui Guo and Lei Sun*, Protocol for the sonogenetic stimulation of mouse brain by non-invasive ultrasound. STAR Protocols, 2021, 2 (2), 100393
[14] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jinghui Guo, and Lei Sun*, Behavioral and functional assessment of ultrasound neuromodulation on Caenorhabditis elegans. IEEE TUFFC, 2021, 68(6), 2150 – 2154
[15] Jinghui Guo, Yong Wu, Zhiyong Gong, Xixi Chen, Fei Cao, shashwati Kala, Zhihai Qiu et al, Photonic nanojet-mediated optogenetics, Advanced Science, accepted.
[16] Zhaoxi Li, Dafeng Wang, Chunlong Fei*, Zhihai Qiu et al, The Forbidden Band and Size Selectivity of Acoustic Radiation Force Trapping, iScience, 2020, 2021, 24(1): 101988.
