王斌
博士，研究员，研究组组长
Email：wangbin@@gdiist.cn
个人简介：
王斌，研究员，脑认知神经网络发育和疾病研究组组长。分别于2003年7月和2006年7月在西北大学生命科学学院获得理学学士和硕士学位。2011年11月毕业于中国科学院上海生命科学研究院，获理学博士学位。2011年12月至2018年12月在中国科学院生物化学与细胞生物学研究所任博士后、副研究员。2019年1月起任上海脑科学与类脑研究中心副研究员。2021年9月起担任广东省智能科学与技术研究院研究员、研究组长。曾获得中国博士后面上以及特别项目、中科院上海生科院博士后以及上海博士后、中国科学院青年创新促进会会员以及国家自然科学基金面上项目等资助。研究成果发表于Cell Research, Cell Reports, EMBO Reports, Brain 和eLife等杂志。
脑认知神经网络发育和疾病研究组：
本课题组致力于脑认知神经网络发育和疾病的机理研究。通过对中国人群先天性智力障碍儿童进行全基因组和非编码RNA测序分析，建立遗传疾病资源库和数据库。结合大数据分析、人工智能机器学习等方法对其中潜在的致病基因及其变异进行筛选。进一步通过构建疾病相关的人类iPSC、类器官及人源化转基因小鼠等研究手段，探索这些基因变异对神经系统细胞功能、小鼠学习、认知和认知相关神经网络连接的影响，揭示其致病性和作用机理，为脑认知障碍疾病的早期筛查和治疗方案提供重要的理论依据。
代表论著：
(1) Wang B#,*,Jiang BW#, Li G-W#, Dong F, Luo Z, Cai B, Wei MY, Huang JS, Wang KK, Feng X, Tong F, Han QJ, Li CL, Zhang X, Yang L* and Bao L* (2022). somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Reports, e54313. DOI: 10.15252/embr.202154313. (# Co-first authors and * Corresponding authors).
(2) Huang JS, Jiang BW, Li G-W, Zheng DD, Li MY, Xie X, Pan YX, Wei MY, Liu XY, Jiang XY, Zhang X, Yang L, Bao L*, Wang B* (2022). m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Reports, 41(8):11693. (* Corresponding authors).
(3) Yin QQ, Sun LB, Cai XJ, Lou FZ, Sun Y, Wang B, Jiang BW, Bao L, Li X, Song NN, Tang SB, Bai J, Wang ZK, Wu Y, Zhou H, Wang H, Yu BW, Li QF, Wang HL (2022). Lidocaine ameliorates psoriasis by obstructing pathogenic CGRP signaling-mediated sensory neuron-derived cell communication. Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2022.01.002.
(4) Wei MY, Huang JS, Li G-W, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* and Wang B* (2021). Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation. Cell Reports, 35 109053, 1-15. (* Corresponding authors).
(5) Pan XY, Zhao JR, Zhou ZY, Chen JJ, Yang ZX, Wu YX, Bai MZ, Jiao Y, Yang Y, Hu XY, Cheng TL, Lu QY, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu JM, Xiao HS, Qiu ZL, Li JS, Wang ZF, Hui JY, Bao L, Zhang X. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021. DOI: https://doi.org/10.7554/eLife.63021.
(6) Jiang BW, Bao L and Wang B* (2019). Isolation of Cell-Type-Specific Neurons in Mouse Dorsal Root Ganglion by FACS. Bio-101 e1010323., 2019, Doi: 10.21769/BioProtoc.1010323. (* Corresponding author)
(7) Wang B and Bao L (2017). Axonal microRNAs: localization, function and regulatory mechanism during axon development. Journal of Molecular Cell Biology, 9: 82-90. (Cover story)
(8) Wang B #, Pan L#, Wei MY, Wang Q, Liu WW, Wang NX, Jiang XY, Zhang X and Bao L (2015). FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 2794-2807. (# Co-first authors)
(9) Chen XQ #, Wang B #, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L (2012). Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Research, 22: 677-696. (# Co-first authors)
(10) Liu XJ, Zhang FX, Liu H, Li KC, Lu YJ, Wu QF, Li JY, Wang B, Wang Q, Lin LB, Zhong YQ, Xiao HS, Bao L, Zhang X (2012). Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135: 391-403.
(11) Ma GQ, Wang B, Wang HB, Wang Q and Bao L (2008). Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 2008; 9: 2165–2179.
