刘学钊
博士，研究员，研究组组长
Email: liuxuezhao@@gdiist.cn
个人简介：
刘学钊，研究员，脑认知与髓鞘发育研究组组长。2006年本科毕业于天津科技大学，2009年硕士毕业于南开大学，2015年于中国科学院大学取得博士学位。于2017年7月至2025年1月在美国辛辛那提儿童医院医学中心从事博士后研究工作。参与完成了美国国家多发性硬化症协会 (National Multiple Sclerosis Society) 的科研项目。 代表性研究成果以第一及共同第一作者身份发表在《Cell》、《Nature Neuroscience》和《Journal of Cell Biology》等国际顶尖期刊上。
脑认知与髓鞘发育研究组
在中枢神经系统的精密网络中，髓鞘作为少突胶质细胞（oligodendrocytes, OLs）构建的功能性鞘状结构，是神经系统高效运作的核心基础。这一由脂质与蛋白质组成的髓鞘层不仅通过绝缘作用将神经信号传导速度提升数十倍，更通过能量代谢调控机制优化神经元的资源利用效率，成为维持神经网络动态平衡的关键环节。
髓鞘发育异常或损伤与神经发育性疾病、认知障碍及神经退行性疾病的发生发展密切相关。最新研究表明，髓鞘细胞还通过分泌神经营养因子、代谢底物等方式，为轴突长期存活与功能维持提供营养支持，其作用已延伸至神经网络的可塑性调控与脑认知功能的基础机制研究。
基于上述科学发现，本研究组从实验动物模型出发，聚焦神经网络的髓鞘化调控机制，通过多尺度成像技术(光镜-电镜关联成像、功能磁共振)、单细胞转录组分析及类器官模型、并结合细胞分子生物学和生物化学等手段，系统解析髓鞘形成对神经环路信息传递效率的调控规律。研究目标旨在揭示髓鞘-神经元-胶质细胞交互作用的分子网络，为神经发育疾病的干预策略及认知功能重塑提供新的理论依据。
代表论著：
1. Liu X*, Xin E*, Zhong X*, Zhao C*, Li Z, Zhang L, Dourson A, Lee L, Mishra S, Bayat A, Nicholson E, Seibel W, Yan B , Mason J, Turner B , Gonsalvez D, Ong W, Chew S, Ghosh B, Yoon S , Xin M, He Z, Tchieu J, Wegner M, Nave K, Franklin R, Dutta R, Trapp B, Hu M, Smith M, Jankowski M, Barton S, He X, and Lu Q.(2024) Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. Apr 25: S0092-8674(24)00400-8. doi: 10.1016/j.cell.2024.04.005
2. Huang G*, Li Z*, Liu X* (Co-first author), Guan M, Zhou S, Zhong X, Zheng T, Xin D, Guo X, Mu D, Guo Y, Zhang L, Zhang L, Lu Q, and He X. (2024) DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice. Nat Neurosci. 2024 Sep 12. doi: 10.1038/s41593-024-01754-9.
3. Liu X*, Li Y*, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W, Yang C. (2017). The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J Cell Biol. 2017 Apr 12. pii: jcb.201608039. doi: 10.1083/jcb.201608039
4. Wang J, Yang L, Du Y, Wang J, Weng Q, Liu X, Nicholson E, Xin M and Lu Q. (2024) BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination. J Cell Biol. 2024;223(7): e202310143. doi:10.1083/jcb.202310143
5. Hu X*, Wu X*, Berry K, Zhao C, Xin D, Ogurek S, Liu X, Zhang L, Luo Z, Sakabe M, Trubicka J, Łastowska M, Szulzewsky F, Holland EC, Lee L, Hu M, Xin M, Lu QR. (2023) Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nat Cell Biol. 2023 Feb;25(2):323-336. doi:10.1038/s41556-022-01069-6.
6. Luo Z*, Xia M*, Shi W*, Zhao C*, Wang J*, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR. (2022) Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022 Dec;612(7941):787-794. doi: 10.1038/s41586-022-05487-2.
7. Wang J, Yang L, Jiang M, Zhao C, Liu X, Berry K, Waisman A, Langseth AJ, Novitch BG, Bergles DE, Nishiyama A, Lu QR. (2022) Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination. J Neurosci. 2022 Nov 9;42(45):8542-8555. doi: 10.1523/JNEUROSCI.0237-22.2022.
8. Wu LMN, Zhang F, Rao R, Adam M, Pollard K, Szabo S, Liu X, Belcher KA, Luo Z, Ogurek S, Reilly C, Zhou X, Zhang L, Rubin J, Chang LS, Xin M, Yu J, Suva M, Pratilas CA, Potter S, Lu QR. (2022) Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Sci Adv. 2022 Nov 4;8(44): eabo5442. doi: 10.1126/sciadv. abo5442.
9. Wang M *, Tang C *, Xing R, Liu X, Han X, Liu Y, Wang L, Yang C, and Guo W. (2021). WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFbeta signaling. Molecular psychiatry 26, 694-709. doi: 10.1038/s41380-018-0307-y.
10. Zhang L *, He X *, Liu X, Zhang F, Huang L.F, Potter A.S, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Roussel MF, Weiss WA, Lu QR. (2019). Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer cell 36, 302-318 e307. doi: 10.1016/j.ccell.2019.07.009
11. He X*, Zhang L*, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR.(2018) A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nat Med. 2018 Mar;24(3):338-351. doi: 10.1038/nm.4483.
12. Li Y, Zhang Y, Gan Q, Xu M, Ding X, Tang G, Liang J, Liu K, Liu X, Wang X, Guo L, Gao Z, Hao X, & Yang C. (2018). C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. Protein & cell 9, 1013-1026. doi: 10.1007/s13238-018-0520-0.
13. Liu K*, Jian Y*, Sun X*, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C. (2016) Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J. Cell Biol.212(2):181-98. doi: 10.1083/jcb.201506081.
14. Li Y*, Xu M*, Ding X, Song Z, Huang X, Jian Y, Tang G, Yan C, Di Y, Liu X, Liu K, Li T, Wang Y, Guo W, Hao X, Yang C.(2016). Protein kinase C is a master switch of lysosome biogenesis independent of mTORC1. Nat Cell Biol. 2016 Oct;18(10):1065-77. doi: 10.1038/ncb3407.
15. Chen D *, Jian Y *, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y & Yang C. (2013). Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in Caenorhabditis elegans. PLOS Genetics, 9(5): e1003517. doi: 10.1371/journal.pgen.1003517.
